NG-CHMs support interactive exploration of patterns in the data through zooming, panning, searching, and advanced link-outs to dozens of external resources. The Interactive CHM Builder produces traditional heat map images as PDF files but can also produce interactive next-generation CHMs (NG-CHMs). One obvious limitation of traditional heat maps is that they contain a huge amount of information but are static in nature and do not readily support a deeper exploration of the biology behind the image. (Caveat: Iterative exploration of different options may introduce a multiple-comparisons issue that would have to be taken into account if the map were used for formal statistical inference, rather than discovery.) The tool guides users through the steps of creating a heat map and supports iterative refinement of the map by working backward and forward through the steps to refine data transformation, annotation, clustering, and formatting options. It can be used by investigators with no bioinformatics experience and only modest exposure to biostatistical methods.
Our Interactive CHM Builder is a web-based tool for data transformation, clustering, and generation of high-quality heat maps.
This is usually not a simple linear process because data transformation and clustering methods are often revisited to find the ideal match for the study, and modifications are often made to heat map visualizations to select the best colors, adjust covariates, insert gaps, etc. Generally, those tasks require the assistance of an analyst with biostatistics or bioinformatics skills who can work in R or a similar language to manipulate the study data and generate the map. Construction of a CHM requires data transformation, application of clustering methods, association of covariate (classification) data, and production of the heat map visualization. I will mark your posting as the answer.Many thousands of publications on genomics studies include clustered heat maps (CHMs) because the hierarchical clustering and intuitive visualization provide insight into the relationships among sample sub-groups and key biological processesĨ. When hitting the F1 key or selecting the Help from the menu pulldown the Help file now appears.Īgain, thank you very much. I published my project and installed it via the Setup.exe. If the file is inserted in another place in all likelihood
On previous attempts the help file was inserted in different places, but on this occasion the CHM file was placed after the forms this may be an important visual clue and is the reason why I mention it. Just so others may benefit from this exercise I take the liberty to include the structure I see in the Solution Explorer: I had added the help file to several locations without success and the published project never included the file.
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